One thing I have found in all the years I've sold homes is that if you can find three (3) things wrong, you need to move on.  One or two are easy to cope with, but three is pushing it.  So, you may be OK with a house that's further from work (strike 1), and has a small closet in the master (strike 2), but if you're looking for a one story, and this house is a two story (strike 3), move on.  Saavy buyers will know within the first few minutes.  Know yourself, and you'll get a great home.  

Use this trick when you're looking for your new place.  It never fails to work!